CBD OIL FOR ULCERATIVE COLITIS: Effective Remedy for Inflamed Large Intestine by Karl BurmerCannabis – a word that stirs a lot of discussion and debate. But when we come to think of it, it is just an herb, a plant that has been used for medicinal, religious, and trading purposes for decades. However, despite its historical merits, it is still considered controversial. Due to its psychotropic effects, it was declared illegal in the 17th century US.
Fortunately, a series of major discoveries about the plant and its connection to the human body prevailed. In 1964, scientists from Israel were able to identify and synthesize the cannabinoid tetrahydocannabinol (THC). Soon after, other cannabinoids were identified including cannabidiol (CBD). Another milestone achieved was in 1988 when scientists determined that the mammalian brain has receptor sites that respond pharmacologically to cannabinoids. These cannabinoid receptors comprise the endocannabinoid system (ECS), a network of specialized protein molecules embedded in cell membranes that affect various homeostatic functions.
Since those discoveries were made, more and more studies emphasizing the therapeutic effects of cannabis have been conducted. These boosted the popularity of CBD oil, a component of cannabis that does not have the same hallucinogenic and mind-altering effect as the whole plant. Today, following the legalization of some states, CBD is slowly making its way to the mainstream pharmacological world.
CBD is one among the 85 known cannabinoids in cannabis. It is often confused and mistaken for THC, cannabis’ intoxicating component that gives the feeling of being “high”. CBD, however, does not trigger the same effect. Rather, it has been proven to have numerous healing properties and it can counteract some negative effects of THC. In various studies, CBD has been identified as anti-inflammatory, anticonvulsant, anti-oxidant, anti-emetic, anti-tumorigenic, analgesic, anxiolytic and antipsychotic. These properties make it a potential medicine for the treatment of numerous diseases.
CBD acts through the endocannabinoid system of the body. It also causes direct or indirect activation of various receptor-independent channels as well as different non-cannabinoid receptors and ion channels. These networks give CBD the ability to induce a variety of effects through multiple molecular pathways. CBD’s interaction with these channels has been the subject of extensive research in the field of pharmacology.
Risk and benefits of cannabis for IBD patients
Cannabis and cannabis oil for the treatment of ulcerative colitis
However, more research is needed—particularly large-scale trials that are randomized and double-blinded, meaning neither the doctors nor the patients know if they are getting the actual treatment or a placebo —before cannabis can be justified as a proven therapy for IBD. Traditionally, the smoking form of cannabis has been called marijuana, although some oral formulations are now also called marijuana. However, cannabis for recreational or medicinal use is illegal by federal law. Contrary to the federal policy, several individual states have passed laws making medical marijuana legal, and a few states have also made recreational use of marijuana legal. Some people with IBD turn to complementary and alternative practices like medical marijuana because it gives them a sense of control over their disease, by giving them something that they can actively do to combat their symptoms. Others feel that options like medical marijuana may have less side effects than other treatments.
Fourteen additional states have legalized cannabis strains with a high cannabidiol CBD to low deltatetrahydrocannabinol THC ratio which is thought to have less psychoactive effects. A total of 13 states have moved to decriminalize cannabis, but not legalize it. The definition of decriminalization varies from state to state. The more robust data on the use of medical cannabis, in the form of randomized, controlled trials, come from the study of patients with neuropathic pain, chronic pain, or multiple sclerosis. There are also limited data in patients with glaucoma, HIV and AIDS cachexia, cancer-related symptoms nausea and vomiting , and posttraumatic stress disorder. Despite improvement in disease activity, many patients have persistent clinical symptoms that have significant impact on their quality of life. Patients have been seeking out alternative therapies including cannabis to help manage persistent symptoms associated with IBD.
Cannabidiol CBD has become popular in recent years to treat a variety of health conditions. CBD, which is derived from the cannabis plant, is widely available for use in different types of products, such as oral supplements or skin products. This article will explore some of the work into how CBD might affect the body and if it could be effective for treating the symptoms of IBD. Keep in mind: a gastroenterologist should be consulted before trying any new therapies to treat IBD. CBD oil is available in a variety of forms.
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The marijuana plant Cannabis sativa and its derivatives, cannabinoids, have grown increasingly popular as a potential therapy for inflammatory bowel disease IBD. Studies have shown that modulation of the endocannabinoid system, which regulates various functions in the body and has been shown to play a key role in the pathogenesis of IBD, has a therapeutic effect in mouse colitis. Epidemiologic data and human therapy studies reveal a possible role for cannabinoids in the symptomatic treatment of IBD, although it has yet to be determined in human populations whether cannabinoids have therapeutic anti-inflammatory effects in IBD or are simply masking its many debilitating symptoms. Large, double-blind, randomized, placebo-controlled trials using serial inflammatory markers, biopsy findings, and endoscopic disease severity to demonstrate objective improvement in IBD are necessary before cannabis can be empirically accepted and recommended as an IBD treatment option. Questions concerning its safety profile and adverse effects prompt the need for further research, particularly in regard to dosing and route of administration to maximize benefits and limit potential harms. Cannabis use should be reserved for symptomatic control in patients with severe IBD refractory to the currently available standard-of-care and complementary and alternative medicines.
Irritable bowel disease IBD is a collection of inflammatory diseases affecting the digestive tract. IBD symptoms include severe cramping, bloating, and diarrhea. These symptoms can be painful and disruptive to your daily life. CBD does, however, have some therapeutic qualities. In addition, people with IBD report improvements in symptoms and quality of life after using it. Keep reading to learn about the different forms of CBD, what types can be used to potentially alleviate symptoms of IBD, and how to determine dosage.