Disposition of Toxic Drugs and Chemicals in Man by Randall C. BaseltBaselt (former director, Chemical Toxicology Institute, Foster City, California) presents essential information on the disposition of chemicals and drugs most frequently encountered in cases of human poisoning. This includes data on body fluid concentrations of substances in normal or therapeutic situations, concentrations in fluids and tissues in instances of toxicity, toxic effects, chemical structures, and brief discussion of analytic procedures for the determination of substances in biological specimens. and the metabolic fate of theses substances in humans. From abacavir to zuclopenthixol, some 600 substances are covered, 139 of which are new to this edition and include animal toxins, antibiotics, antidepressants, antifungal agents, antiviral agents, diuretics, herbal medicines, herbicides, laxatives, solvents, sedative- hypnotics, pesticides, and drugs used to treat Alzheimers disease. Page count has been kept about the same by reducing type size. Annotation ©2005 Book News, Inc., Portland, OR
Disposition of Toxic Drugs and Chemicals in Man
ISBN 13: 9780692774991
Skip to search form Skip to main content. Baselt Published DOI: The preface indicates that substances have been added in the new edition, bringing the total to around This is clearly a work in progress, as the changes from previous editions are listed: addition of CAS Chemical Abstracts Service numbers, molecular weight and empirical formula, amongst others. View PDF.
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Add to Cart. Overview The objective of this text has always been to allow an assessment of the degree of chemical exposure based on the analytical determination in human biological specimens of the quantitative presence of the most frequently encountered substances, or of a physiological parameter reflecting their presence., Updating results
It was immediately obvious that the eighth edition was thicker and heavier than the fifth, and I was excited to see what the newest edition had to offer. Although the fifth edition lists only 2 oxycodone metabolites, I was pleased to see the eighth edition included structures for 6 metabolites. New drugs included in the latest edition cover the spectrum of compounds recently approved for human use antibiotics to vasodilators. The format for each entry is very similar to previous editions. Entries are listed alphabetically and consist of the compound name and chemical structure along with information regarding half-life, volume of distribution, fraction bound to protein, and dissociation constants.
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